Description

Tesamorelin (RUO) – Research-Grade Peptide | COA Verified | USA

Product Specifications

• Product Name : Tesamorelin (Tesamorelin Acetate)
• Product Type : Synthetic GHRH Analogue (Growth Hormone-Releasing Hormone)
• Sequence Length : 44 Amino Acids
• Molecular Weight : ~5135.9 Da
• Purity : ≥99% (HPLC Verified)
• Solubility : Compatible with commonly used laboratory-grade aqueous solvents
• Form : Lyophilized Powder
• Storage : Store at -20°C, protected from light and moisture

Disclaimer

For Research Use Only (RUO). Not for human use.

 

Description

 

Chemical Identity & Characteristics

 

Tesamorelin is a 44-amino acid polypeptide sequence homologous to the N-terminal fragment of human GHRH. It is distinct from native GHRH due to a specific N-terminal modification: the addition of a trans-3-hexenoyl group.

 

In research applications, this hexenoyl moiety is investigated for its ability to provide steric shielding, potentially increasing resistance to enzymatic cleavage by dipeptidyl peptidase-4
(DPP-4) in experimental substrates. This structural modification is a key subject of study regarding peptide stability and pharmacodynamics compared to native GHRH sequences.

 

 

Molecular characteristics of Tesamorelin

 

highlighting the N-terminal modification utilized in stability research.

 

illustration of the Tesamorelin peptide, showing its peptide chain structure with highlighted functional groups and the compound name labeled underneath.

 

Analytical Validation & Certificate of Analysis (COA)

 

Profound Aminos places a strong emphasis on analytical transparency across all research materials. Every batch of Tesamorelin is thoroughly tested to confirm both identity and purity.

 

• High-Performance Liquid Chromatography (HPLC) : Evaluates peptide purity and helps detect possible impurities.
• Mass Spectrometry (MS) : Confirms molecular weight (≈ 5135.9 Da) and verifies sequence identity.

 

A Certificate of Analysis (COA) is provided for each lot, giving researchers clear traceability and assurance that the material meets stringent specifications and has been properly characterized prior to shipment.

 

Storage, Stability & Handling (RUO)

 

This product is supplied as a sterile, lyophilized powder. To maintain stability and integrity:

 

• Storage : Vials should be stored at -20°C in a freezer.
• Protection : Keep vials away from direct light and moisture.
• Reconstitution : For laboratory preparation and analytical procedures only. Once reconstituted, the solution should be handled according to standard laboratory protocols for peptide stability, typically requiring refrigeration and use within a short timeframe.

 

This material is hygroscopic and should be allowed to reach room temperature before opening to prevent moisture absorption.

 

Research Context & Literature Overview

 

Tesamorelin has been the subject of extensive investigation in metabolic and neuroendocrine research. Scientific literature describes the compound as a GHRH agonist that binds to specific receptors on anterior pituitary somatotrophs.

 

Published studies report the following mechanistic observations :

 

Somatotropic Axis : Research indicates that the compound may stimulate the release of endogenous growth hormone (GH) in a pulsatile manner in test subjects, maintaining negative feedback loops via IGF-1.

 

Lipolytic Pathways : Preclinical models have explored the peptide’s selectivity for visceral adipose tissue modulation, investigating enzyme regulation such as lipoprotein lipase (LPL) and hormone-sensitive lipase (HSL).

 

Hepatic Research : Studies have examined the effects of GHRH analogues on hepatic physiology, specifically regarding mitochondrial oxidation and de novo lipogenesis pathways in models of hepatic steatosis.

 

Neuroregeneration : Emerging research (e.g., Johns Hopkins University) is currently investigating the potential role of GHRH agonists in peripheral nerve regeneration and axonal outgrowth in injury models.

 

Cited Research & Clinical Literature

 

Multiple high-impact, peer-reviewed journals have published findings on Tesamorelin’s characterization. These references are provided for educational and research purposes only.

 

New England Journal of Medicine (2007) :

 

• Study: “Metabolic effects of a growth hormone-releasing factor in patients with HIV.” (Grinspoon et al.)
• Summary: A foundational study characterizing the metabolic profile and pharmacodynamics of the peptide in specific metabolic dysregulation cohorts.

 

The Lancet HIV (2019) :

 

• Study: “Effects of tesamorelin on non-alcoholic fatty liver disease in HIV.” (Stanley et al.)
• Summary: Documented the effects of the peptide on hepatic fat fraction and fibrosis markers in randomized controlled settings, providing data on hepatic gene expression modulation.

 

Journal of Clinical Endocrinology & Metabolism (2010) :

 

• Study: “Effects of tesamorelin… a pooled analysis of two multicenter, double-blind placebo-controlled phase 3 trials.” (Falutz et al.)
• Summary: Detailed the efficacy data regarding visceral adipose tissue modulation and safety parameters in large-scale study populations.

 

AIDS (2024) :

 

• Study: “Efficacy and Safety of Tesamorelin in People with HIV on Integrase Inhibitors.” (Russo et al.)
• Summary: A recent analysis examining the peptide’s interaction with modern antiretroviral regimens and its influence on visceral adiposity and hepatic parameters.

 

Why Researchers Source from Profound Aminos

 

Profound Aminos provides peptides with a focus on analytical transparency, batch-level traceability, and rigorous RUO compliance to help enable reliable, reproducible research.

 

Traceability : Verified batch data is provided so you can confirm exactly what’s in your reagent.

 

Documentation : Clear, easy-to-access COAs support your lab’s quality control needs.

 

Compliance : A strict Research Use Only policy ensures products are available only to qualified researchers for legitimate scientific work.

 

Integrity : Peptides are handled and stored under controlled conditions to help preserve experimental reliability.

 

Scientific Reference Disclaimer

 

The literature citations and research context provided above are strictly for scientific and educational purposes to describe the peptide’s mechanism of action and history in research. They do not imply efficacy, safety, or therapeutic use. This product is a chemical reagent and has not been approved for any medical application.

 

Regulatory & Compliance Statement

 

For Research Use Only (RUO).

 

This product is intended solely for laboratory research and development. It is not for human or veterinary use. It is not a food, drug, or cosmetic.

 

No medical, therapeutic, or diagnostic claims are made regarding this product. All handling must be performed by qualified professionals in a laboratory setting.

 

 

FAQs :

 

Is this peptide for research use only?

 

Yes. CagriSema is supplied strictly for laboratory research and analytical use. It is not for human consumption or therapeutic administration.

 

Is a Certificate of Analysis (COA) available?

 

Yes. A batch-specific Certificate of Analysis (COA) demonstrating HPLC and MS data is available for review and verification.

 

How is purity verified?

 

Purity is verified using High-Performance Liquid Chromatography (HPLC) to ensure the compound meets research-grade specifications (≥99%).

 

Is USA shipping available?

 

Yes. We ship directly from our facility within the USA to ensure fast delivery and product stability.